We evaluated changes in hormones (T, LH, FSH, and estradiol), HCT, HbA1c, and PSA before and after initiating hCG monotherapy. We retrospectively analyzed the charts of 28 men with previous exogenous T use who visited our urology clinic and were subsequently on hCG monotherapy for at least one month with follow-up labs. Patients were excluded if they were on other forms of T therapy (such as clomiphene, anastrozole, or T) concurrently with hCG or did not have a follow-up testosterone laboratory result after at least one month.
If someone is having low Testosterone symptoms & they have primary or secondary hy... In general HCG monotherapy's effectiveness it based on someone's baseline production ability, much like Enclomiphene. Primary (testicular failure) hypogonadism responds only...
It’s often recommended for men looking to maintain fertility or those concerned about potential side effects of traditional TRT, like testicular shrinkage or diminished sperm production. Administering HCG can help boost natural testosterone production without directly introducing external testosterone. LH is responsible for stimulating the testes to produce testosterone. HCG is a hormone produced during pregnancy that also closely mimics Luteinizing Hormone (LH) in men. Here’s an in-depth look at the pros and cons of HCG monotherapy to help you determine if it’s the right approach. But like any treatment, it has its benefits and drawbacks.
This recommendation was determined based on a compromise between the inclusion criteria testosterone (less than 350 ng/dL) and the median testosterone levels (250 ng/dL) of most large testosterone therapy trials over the past decade, in part to minimize overtreatment of patients (8). We evaluated patient age, treatment indication, hCG dosage, past medical history, physical exam findings and serum testosterone and gonadotropins before and after therapy. For symptomatic patients whose serum testosterone is at the lower limit of the adult reference range, a short therapeutic trial of testosterone can be prescribed to assess the effectiveness of the therapy. For patients with secondary hypogonadism who desire fertility, replacement with subcutaneous injection of gonadotropins, hCG or human recombinant FSH can be used to induce testosterone production by the testis and spermatogenesis. Another estrogen partial antagonist Tamoxifen has been used in elevating serum LH and FSH and serum testosterone levels in infertile and hypogonadal men .
Among the entire cohort, HCT levels showed a small but statistically significant decrease, and no VTEs or MACEs were recorded. Although it appears that hCG therapy may decrease HCT, we did not specifically test this in men with secondary erythrocytosis. La Vignera’s findings suggest that hCG may offer a safer form of T therapy, which is consistent with our results. The decrease in PSA demonstrated here further supports hCG’s safety and the increase in T validates its effectiveness.